[431 0 R 431 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R 436 0 R 437 0 R 235 0 R] 453 0 obj Degradation to primary bile acids represents the most relevant mechanism of irreversible elimination of cholesterol from the body, thus playing a key role in hepatic and systemic cholesterol homeostasis. 400 0 obj /T1_0 1 Tf 10 0 0 10 109 368.99994 Tm 536 0 obj [403 0 R 404 0 R 405 0 R 406 0 R 407 0 R 408 0 R 409 0 R 410 0 R 230 0 R] 4.44499 1 Td 501 0 obj DOI: 10.1038/embor.2011.205 Corpus ID: 8170940. 204 0 obj endobj Maximum cholesterol degradation by the isolates occurred in the cholesterol medium (Medium-A), where cholesterol (1 g/L) was supplemented with as a sole carbon source for 6 d. Approx, 65-80% of the cholesterol was degraded by the isolates (Table 2). ՝/�I��QI������`��n�.��&���[b��\b]���OB^�6��ۙB4��m��������S�Q$�jWP�w&��[�~t��S�o? <>stream 0 0 1 rg Degradation of EGFR through APMAP Siyuan Jiang1, Xuetong Wang1, Dalong Song2, XiaoJun Liu1,Yinmin Gu1, ... High cholesterol inhibits EGFR internalization by promoting the competitive binding of APMAP to EPS15R, which in turn activates ERK1/2 to promote epithelial-to-mesenchymal transition. <> ( )Tj 468 0 obj [369 0 R 370 0 R 371 0 R 372 0 R 373 0 R 374 0 R 375 0 R 376 0 R 377 0 R 378 0 R 379 0 R 380 0 R 381 0 R 382 0 R 383 0 R] 495 0 obj <>stream 150 0 obj endobj ACKNOWLEDGEMENTS The se last p ages of a PhD thesis a re usually the most widely re ad pages of the entire publication. endobj /T1_3 1 Tf <> Both the isolates S. marcescens W1 and B. pumilus W8 showed increased cholesterol degradation with increasing concentration of cholesterol from 0.5 up to 1.0 g/L, while further increase in concentration of cholesterol reduced the degradation (Figure 2(b)).Maximum degradation of cholesterol (54.6% and 57.6%) was observed with Serratia marcescens W1 and … 475 0 obj 452 0 obj 2020-12-27T13:19:36-08:00 /T1_0 1 Tf 454 0 obj <> <> endobj endobj Cholesterol accelerated the proteasomal degradation of SM which required the N-terminal domain, partially conserved in vertebrates but not in lower organisms. [420 0 R 421 0 R 422 0 R 423 0 R 233 0 R] endobj endobj <> endobj Phytosterols and cholesterol share a similar chemical structure, and undergo oxidation during food processing and storage. 203 0 obj Degradation of Cationized Low Density Lipoprotein and Regulation of Cholesterol Metabolism in Homozygous Familial Hypercholesterolemia Fibroblasts <> ET BT <>stream 19.67698 1 Td 465 0 obj H��WkS�J��_��I�-���o�{/�6��wkK���W�P�_�3�L�r�&U�T==�8}�̟�yNx��? Links to PubMed are also available for Selected References. endobj endobj 0 g The bile acids are synthesized in the liver from cholesterol. Substrate Concentration. 0 0 1 rg /T1_0 1 Tf Acrobat 4.0 Capture Plug-in for Windows HepG2 cells and HuH-7 cells both originated from a human hepatoma and endogenously express ABCA1. 218 0 obj endobj Keywords: 7-dehydrocholesterol, cholesterol, DHCR7, degradation, vitamin D ABSTRACT . ( )Tj S. C. §1734solely toindicate Downloaded by guest on … 10 0 0 10 120.11996 399 Tm -4.44499 0 Td This paper studied the degradation of cholesterol and three plant sterols during a 360 min heating treatment (180ºC). (This article cites 0 references, 0 of which can be)Tj 471 0 obj <> <> endstream uuid:a6809487-1dd1-11b2-0a00-530927bdd100 <> endobj endobj 212 0 obj 493 0 obj [396 0 R 397 0 R 398 0 R 447 0 R 448 0 R 448 0 R 448 0 R 449 0 R 450 0 R 450 0 R 450 0 R 450 0 R 451 0 R 452 0 R 452 0 R 452 0 R 452 0 R 452 0 R 452 0 R 452 0 R 453 0 R 454 0 R 454 0 R 454 0 R 454 0 R 454 0 R 454 0 R 455 0 R 456 0 R 457 0 R 458 0 R 459 0 R 460 0 R 461 0 R 462 0 R 463 0 R 464 0 R 465 0 R 466 0 R 467 0 R 468 0 R 469 0 R 470 0 R 471 0 R 472 0 R 473 0 R 474 0 R 475 0 R 400 0 R 401 0 R 402 0 R] application/pdf endobj %PDF-1.4 %���� application/pdf 505 0 obj 473 0 obj FK�`�����I.4�3`>��nX�s�ƎQ&��"X.8�V'�?5���`d������"k�^z�&��[Z��0By ��Gc�HP9���AV[�qҲ�MN�gMC��7�����j�4o�|���+ �E� �����ug��!���G������~^���C:��� Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH @article{Surdo2011MechanisticIF, title={Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH}, author={Paola Lo Surdo and Matthew J. Bottomley and A. Calzetta and Ethan C Settembre and A. <> [291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R 301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R] PDF | On Jun 14, 2019, Fadhil Jawad Altu'ma published Cholesterol Metabolism | Find, read and cite all the research you need on ResearchGate. 447 0 obj <> endobj endobj Many types of cholesterol oxidation products have been found in different food products and their negative biological activities have been extensively reviewed (Gill et al., 2008, Otaegui-Arrazola et al., 2010, Paniangvait et al., 1995). 89 468 m uuid:f2996e4f-1dd1-11b2-0a00-bf0000000000 <> 207 0 obj <> <> 472 0 obj DOI: 10.1074/jbc.M113.515890 Corpus ID: 10279237. [307 0 R 308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R 316 0 R 317 0 R 318 0 R 319 0 R 320 0 R] endobj 514 DEGRADATION OF CHOLESTEROL diluted to 10 ml. 488 0 obj 2020-12-27T13:19:36-08:00 490 0 obj endobj endobj 449 0 obj BT (\240 )Tj endobj Cholesterol increases the risk of aggressive pros- <>stream 497 0 obj <>/MediaBox[0 0 609.84 792.12]/Parent 534 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 21/Tabs/S/Type/Page>> endobj 466 0 obj The formation and further degradation of SOPs was also analyzed by GC-MS. 468 0 obj 10 0 0 10 89 413.99994 Tm ET 205 0 obj 312 468 l uuid:f282d8e4-1dd1-11b2-0a00-1e00c807b0ff H��W[o۸~ϯࣵX˼SZ���Ӄ؞xq���M'���:��ߡ$�#�T�8yHb�3�����Ofﶻ���厼y3{��-.o�+r1;��v��:�?�Wd��by�^�n7k�����{r2�������l>����J2�>Q��Z�rY���ɄI�����X�5��ȵ�d�DN��������,�O���L�����l����3B����e�h�rE�g'�y&sJ�d�.Sdr�M5|��$�O��C&�ʐ�yFseJ�@�:��8�0P��sm���7y�� G���]�M�G�M+�'@��L7�R��Fm�.&����u�Z�n�R����-8�����QXeL���hP�M�`e����4�p���_@�)�������M�q�W�,S�P��L~D�d*�� �QQZq@�Oƨ]�eSP�8{�Ycq6�5������l����^�և (DEGRADATION OF CHOLESTEROL)Tj 496 0 obj 183 0 obj -3.985 1 Td 405 0 obj [539 0 R] endobj endobj 396 0 obj <> endobj 451 0 obj endobj We present in this study the potential of Gordonia cholesterolivorans to use cholesterol as the only car-bon and energy source for … ... synthesis and degradation of the enzyme. [268 0 R 269 0 R 270 0 R 271 0 R 272 0 R 273 0 R 274 0 R] endobj <> endobj Contain 24 carbon atoms, 2 or 3 OH groups in steroid nucleus & a side chain ending in carboxyl group. ET [443 0 R 444 0 R 445 0 R 446 0 R 237 0 R] 1 0 obj (tml#ref-list-1)Tj 200 0 obj endobj 535 0 obj F���L�&֖��|����nή� D�w�p�2�1ѥ�m:�ݤ�e��7A��&�>4L��x�a��:ǹ�=*�x3#�NJ�]%r%��c�?7��������6�u�Ij~�| Υu�;�]�H���Y>�Pq-1���'�z�,7λ5�<8�I{@�"F~�$C��ιo#S3���R�{[s�p z\��k��x����3"l�$�as�=����E`$Ȩ�7EՖ �6��W��>�/a�ĕ��KR� endobj 3.3.2. %PDF-1.5 %���� 0 g <> <> (alerts)Tj <> (Christian B. Anfinsen)Tj *s�Ar��b39��A�i=�}���L�Ok�a��P�+Fr�t���v-���)+��$a�4 endobj endobj /T1_3 1 Tf BT <> endobj <> (Downloaded from )Tj endobj <> endobj 217 0 obj 504 0 obj <> -0.906 0 Td 472 0 obj BT with CHCL, and read at 390 rnp against a reagent blank. endobj endobj endobj endobj 219 0 obj endstream [411 0 R 412 0 R 413 0 R 414 0 R 231 0 R] (When this article is cited)Tj (Access the most updated version of this article at )Tj <> endobj Acrobat 4.0 Import Plug-in for Windows endobj 459 0 obj endobj 485 0 obj endobj <> 390 0 obj 0 g (When a correction for this article is posted)Tj endobj Direct visualization with fluorescence microscopy Microsoft® Word 2010 Examination of cholesterol utilization dur-ing mycobacterial growth using the coupled cholesterol- endobj Brown and C. … <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> 0 1 TD endobj 0 0 1 rg /T1_3 1 Tf /T1_0 1 Tf '����~���Z�`Ϩ��,��MSdF��$i��SI9�GM@\}/���coz�RjO]b�Đt�@a�[Um����P�O���O�:D��iH ����Lq�wI���b��AY��S+@`v#%@��q�� ��79R�!�5F��ȉgy�� �xȃI9^�H,�)8>/�%*K�=�Eq2�Y����d����Ve8�������^T��(�hŇ��\��/e���o��Zy. 2004). endobj <> mRNA stability, translation, enzyme phosphorylation and enzyme degradation. 0 g (http://www.jbc.org/)Tj ��e����8h��c����&��@�5�����y�;,�toQ�������q��v�8��[�&�,2��)�)�F6R�ֲ�����i�`0�]��2�����)+���т���� endobj endobj <> (J. Biol. 492 0 obj endobj ET <> endobj <>/ProcSet[/PDF/Text]>>/Type/Page>> 464 0 obj well documented (7, 9, 19, 27, 32, 33), but the degradation of cholesterol by a member of the genus Gordonia was reported only recently (8). 17 0 obj endobj [250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R] Cholesterol accumulation and degradation by mycobacteria Three different experimental approaches were used to de-termine cholesterol utilization by mycobacteria, specifically colorimetric determination of cholesterol levels, TLC, and HPLC analysis. f �-��2DaV:���`P�pt�|5[&�ޟ���' ~��%.�_�� T�� /=�M�j1 Nֺ���^Ž\���K���a��c�-A�W Ae�5W�2�,V�����W!A�k�ʐA�z���ǖ��0D���T, Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis. 315 0 obj Sterol regulatory element-binding proteins (SREBPs) are transcription factors that control production of cholesterol and other lipids. <> [506 0 R] endobj 0 g 0 1.00001 TD endobj The isolated microorganisms were grown in the 0 0 1 rg 11.68699 1.00001 Td 282 0 obj 12 0 0 12 143.99991 509.99991 Tm [259 0 R 259 0 R 259 0 R 259 0 R 259 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R] );�aa(B��L9���n�Jb�������?vG��־)'_�j�R�?�l毕��ywe���h>������%�e��!��/��M����+�2�Rg�������t~y|5��οv^e�L4��F91_���n���dz닳�pc�x/V���D#{����\ the five subjects weighed 72.3, 66.8, 102.3, 68.2, and 65.7 kg, respectively, the total dietary intake was adjusted for each individual to maintain a constant (± 1.0 kg) body weight during the course of the experiment. 348 0 obj 220 0 obj <> ARTICLE Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol Bao-Liang Song,1 Norman B. Javitt,2 and Russell A. DeBose-Boyd1,* 1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 2Department of Pediatrics and Medicine, New York University School of Medicine, New York, … 2020-12-27T13:19:22-08:00 (Thressa C. Stadtman, Amelia Cherkes and)Tj endobj endobj endobj 10 0 0 10 154.01996 492 Tm Chem.\240)Tj S T* endobj 214 0 obj -0.22452 1.00001 Td (\240)Tj BT (\225\240 )Tj <> endobj 467 0 obj 211 0 obj <> However, the degradation or oxidation of quercetin remained unknown. degradation of cholesterol 1. Under physiological conditions, approximately 300–400 mg of cholesterol are disposed of in the liver daily, through this pathway [3]. endobj 450 0 obj Unlike HMGR, SM degradation is not mediated by Insig, 24,25-dihydrolanosterol, or side-chain oxysterols, but rather by cholesterol itself. Normal cholesterol levels are strictly maintained by de novo synthesis and degradation and cells can sense their level of cholesterol through the membrane-bound sterol regulatory element-binding protein (SREBP) (Brown and Goldstein, 1997). In endoplasmic reticulum (ER) membranes, SREBPs form complexes with Scap, a cholesterol-sensing membrane protein. endobj In these preparations cholesterol degradation was further enhanced by\ud growth of R. equi No. (Click here)Tj <> ET 222 0 obj 201 0 obj -5.49997 0 Td endobj endobj 398 0 obj 455 0 obj Cholesterol is detrimental to human health in excess, but is also essential for normal embryogenesis. ( to choose from all of JBC's e-mail)Tj ET <> endobj <> 224 0 obj STABILITY AND DEGRADATION STUDIES OF CHOLESTEROL-LOWERING STATIN DRUGS MAŁGORZATA PIECHA DISSERTATION Mentor: Prof. dr. Polonca Trebše Nova Gorica, 2009 . endobj 457 0 obj ET <> <> 215 0 obj 10 0 0 10 89 343.99997 Tm [384 0 R 385 0 R 386 0 R 387 0 R 388 0 R 389 0 R 390 0 R 391 0 R 392 0 R 393 0 R 394 0 R 395 0 R] endobj -7.88899 0 Td -0.66701 1 Td endobj [284 0 R 285 0 R 286 0 R 287 0 R 288 0 R 289 0 R 290 0 R] 470 0 obj endobj cholesterol content.21 Therefore, GW3965, an LXR agonist, can induce cellular response to cholesterol accumulation in the cells and was used to examine effects of cholesterol accumulation on the degradation of csABCA1. e�);Nb|��y0���. 503 0 obj <> <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 500 0 obj endobj 474 0 obj <> <> endobj 209 0 obj Get a printable copy (PDF file) of the complete article (2.5M), or click on a page image below to browse page by page. <> -19.67698 0 Td <> 216 0 obj ( )Tj 460 0 obj endobj It was suggested that hypolipidemic activity of okra was mediated most likely by upregulation of cholesterol degradation through CYP7A1 and by inhibition of lipogenesis through SREBP1c and FAS. brown lab Cellular cholesterol levels are also modulated by a cycle of cholesterol esterification by acyl- CoA : cholesterol acyltransferase (ACAT) and hydrolysis of the cholesteryl esters, and by cholesterol metabolism to … [225 0 R 226 0 R 227 0 R 228 0 R 229 0 R 238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R 248 0 R 249 0 R] [424 0 R 425 0 R 426 0 R 427 0 R 428 0 R 429 0 R 430 0 R 234 0 R] 487 0 obj Hence, enzymes involved in its synthesis possess many layers of regulation to achieve balanced cholesterol levels. BT <> 469 0 obj endobj 469 0 obj 2016-02-09T17:57:47+11:00 ( by guest on December 27, 2020)Tj Introduction to Cholesterol Metabolism. 0 0 m (http://www.jbc.org/content/206/2/511.citation)Tj 0 g [339 0 R 340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R 346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R 356 0 R] endobj 7- endobj (accessed free at)Tj [275 0 R 276 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R 283 0 R] /T1_2 1 Tf -0.906 0 Td endobj <>stream BT 407 0 obj (\240 )Tj 494 0 obj endobj endobj -6.502 0 Td <> <>/Metadata 502 0 R/Pages 2 0 R/StructTreeRoot 3 0 R/Type/Catalog>> endobj Cholesterol is an extremely important biological molecule that has roles in membrane structure as well as being a precursor for the synthesis of the steroid hormones, the bile acids, and vitamin D.Both dietary cholesterol, and that synthesized de novo, are transported through the circulation in lipoprotein particles. <> During cholesterol degradation, three further intermediate compounds were identified by their characteristic mass spectrum, namely, 26-hydroxycholest-4-en-3-one (m/z 401), 26-hydroxycholesta-1,4-dien-3-one (m/z 399), and cholest-4-en-3-one-26-oic acid (m/z 415) in parallel to cholest-4-en-3-one. <> endobj /T1_1 1 Tf endobj 2003-02-19T11:44:14+05:30 <> endstream 408 0 obj <> Full text Full text is available as a scanned copy of the original print version. [415 0 R 416 0 R 417 0 R 418 0 R 419 0 R 232 0 R] endobj Cholesterol (50%) is converted to bile acids (excreted in feces), serves as a precursor for the synthesis of steroid hormones, vitamin D, coprostanol & cholestanol. endobj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> ET Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis thermal degradation of cholesterol were reduced greatly after incorporation of quercetin [17]. endobj Cholesterol homeostasis is vital for proper cellular and systemic functions. 448 0 obj endobj <> 402 0 obj … [438 0 R 439 0 R 440 0 R 441 0 R 442 0 R 236 0 R] 3 0 obj endobj 221 0 obj Cellular Cholesterol Regulates Ubiquitination and Degradation of the Cholesterol Export Proteins ABCA1 and ABCG1* @article{Hsieh2014CellularCR, title={Cellular Cholesterol Regulates Ubiquitination and Degradation of the Cholesterol Export Proteins ABCA1 and ABCG1*}, author={V. Hsieh and Mi-Jurng Kim and I. Gelissen and A. <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj endobj In this report, our objective was to develop an integral mathematic model for studying the thermal degradation or oxidation of quercetin in the presence and absence of cholesterol. 202 0 obj 210 0 obj With dialyzed preparations, it was possible to follow cholestenone for- mation from cholesterol by measuring the increase in absorption at 240 rnp in 90 per cent ethanol extracts. T* The maximum cholesterol degradation (about 90%) was obtained on the third day. 486 0 obj Cholesterol (from the Ancient Greek chole-() and stereos (solid), followed by the chemical suffix-ol for an alcohol) is an organic molecule.It is a sterol (or modified steroid), a type of lipid. 5.49997 1 Td 23 cells used as the inoculum in UHT milk rather than in an\ud artificial medium, prior to determination of cholesterol degradation.\ud The cholesterol degrading system of R. equi No. (\225\240 )Tj )Tj 213 0 obj 0 0 1 rg 19.52397 1 Td -10.78099 0 Td 206 0 obj <> endobj [321 0 R 322 0 R 323 0 R 324 0 R 325 0 R 326 0 R 327 0 R 328 0 R 329 0 R 330 0 R 331 0 R 332 0 R 333 0 R 334 0 R 335 0 R 336 0 R 337 0 R 338 0 R] 2 0 obj <> -7.55399 0 Td 397 0 obj (Alerts: )Tj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> 4-cholesten-3-one was detected as a degradation product of cholesterol by Leuconostoc mesenteroides GMK03. (\240 )Tj Microsoft® Word 2010 216 0 obj 401 0 obj Brain cholesterol is catabolized to 24S-hydroxycholesterol (24S-OHC) by the neuron-specific endobj /T1_3 1 Tf 0 0 1 rg endobj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> 498 0 obj endobj 2020-12-27T13:19:22-08:00 -18.61797 0 Td 456 0 obj <> endobj The studied strains degrade cholesterol by different mechanisms and may suggest a new possibility for the mechanism underlying cholesterol degradation by LAB. 491 0 obj [492 0 R 493 0 R 494 0 R 495 0 R 496 0 R 497 0 R 498 0 R] <> BT The bacterial degradation of cholesterol has been known to occur by a cholesterol oxidase (cholesterol : oxygen oxidoreductase, EC 1.1.3.6), the enzyme which catalyses the oxidation of cholesterol to 4‐cholesten‐3‐one, along with the reduction … The subjects were divided into two groups (A and B), each group receving the butter containing diet (B) during one period and the safflower oil containing diet (S) during another 461 0 obj 10 0 0 10 89 278.99988 Tm <> 499 0 obj uuid:f2996e4c-1dd1-11b2-0a00-ad09271d5700 462 0 obj /T1_0 1 Tf 0 -8 8 0 380 314.10809 Tm Free fulltext PDF articles from hundreds of disciplines, all in one place Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment (pdf) | Paperity <> -3.112 0 Td BT endobj 208 0 obj 223 0 obj endobj Thisarticle mustthereforebeherebymarked"ad-vertisement"inaccordancewith 18U. endobj 502 0 obj <> 489 0 obj (1954, 206:511-523. <> <> <> 1.P.47 Degradation of pyrene-labeled cholesterol esters by lysosomal lipase in vitro and in vivo. Cholesterol and phytosterols can suffer oxidation under heating conditions to give Sterol Oxidation Products (SOPs), known by their toxic effects. 410 0 obj endobj endobj (STUDIES ON THE MICROBIOLOGICAL)Tj 463 0 obj ( )Tj [357 0 R 358 0 R 359 0 R 360 0 R 361 0 R 362 0 R 363 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 364 0 R 365 0 R 366 0 R 367 0 R 368 0 R] L-a-distearoyl phosphatidylcholine; CH,cholesterol. <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> 502 0 obj 4030 Thepublication costs of this article weredefrayed in part by page chargepayment. endobj 458 0 obj When cholesterol levels are low, Scap escorts SREBPs from the ER to the Golgi where proteolytic cleavage releases the transcription factor … /T1_3 1 Tf 249 0 obj <> /T1_0 1 Tf endobj endobj <> (http://www.jbc.org/content/206/2/511.citation.full.h)Tj Okra raw and fractionated polysaccharide showed strong bile acid binding capacity in vitro , which may contribute to the hypolipidemic activity observed. <> Cell Reports Report GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation Steve Poirier,1,2 Maya Mamarbachi,1 Wan-Ting Chen,3 Amy S. Lee,3 and Gaetan Mayer1,2,4,* 1Laboratory of Molecular Cell Biology, Montreal Heart Institute, Montre´al, QC H1T 1C8, Canada 2Department of Pharmacology, Faculty of Medicine, Universite ´de Montreal, Montreal, QC … ET endobj
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